Research Interest

The primary goal of my research is to understand the fundamental properties that govern signal transduction. In particular, I am interested in how dynamic cellular behavior (such as protection of the ischemic myocardium) can be attributed to hierarchical relationships within protein networks.

This overall goal is pursued in three main projects. First, we are examining the formation of multiprotein complexes at subcellular organelles to determine how changes in the constituents of these complexes alter phenotype. Second, we are studying the behavior of tyrosine kinase modules (such as Bmx) in protection of the ischemic heart and in the development of heart failure. Third, we are examining structure-function relationships in cardiac protein networks.

Repesentative Publications

Vondriska TM, Wang Y. A new (heat) shocking player in cardiac hypertrophy. Circ Res. 2008. 103:1194-6.

Mitchell-Jordan S, Holopainen T, Ren S, Wang S, Zhang M, Warburton S, Alitalo K, Wang Y, Vondriska TM. Loss of Bmx non-receptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Circ Res. 2008;103:1359-62.

Qu Z, Vondriska TM. Effects of cascade length, kinetics and feedback loops on biological signal transduction dynamics in a simplified cascade model. Phys Biol. 2008.

Yang L, Vondriska TM, Han Z, MacLellan WR, Weiss JN, Qu Z. Deducing topology of protein-protein interaction networks from experimentally measured subnetworks. BMC Bioinformatics. 2008;9:301.

Vondriska TM, Ping P. Multiprotein signaling complexes and regulation of cardiac phenotype. J Mol Cell Cardiol. 2003;35:1027-1033.

Vondriska TM, Zhang J, Song C, Tang XL, Cao X, Baines CP, Pass JM, Bolli R, Ping P. PKCe-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling. Circ Res. 2001; 88:1306-1313.

Vondriska TM, Klein JB, Ping P. Use of functional proteomics to investigate PKCe-mediated cardioprotection: the signaling module hypothesis. Am J Physiol. 2001;280: H1434-H1441.