Biovasculature Movie

Curriculum Vitae

Research Interest

The main interest in my lab is understanding the molecular mechanisms that regulate cardiac growth, both proliferative and hypertrophic. We extensively use genetic murine models in an attempt to correlate molecular insights with whole organ physiology. The long-term goal of my research is to determine the consequences of the cardiac myocyte cell cycle exit in diseases such as congestive heart failure and understand how hypertrophic growth can lead to left ventricular failure. Ultimately, we hope to identify molecular targets that would allow targeted therapy to regenerate myocardium.

Representative Publications

MacLellan, W.R., Xiao, G., Abdellatif, M., and Schneider, M.D. (2000) A novel Rb- and p300-binding protein regulates transactivation by MyoD. Mol. Cell. Biol. 20(23):8903-8915.

MacLellan, W.R., and Schneider, M.D. (2000) Genetic dissection of cardiac growth control pathways. Ann. Rev. Physiol. 62:289-319.

MacLellan, W.R., (2000) Advances in the molecular mechanisms of heart failure. Curr. Opin. Card. 15:128-135.

Sivasubramanian, N., Coker, M., Kurrelmeyer, K., MacLellan, W.R., DeMayo, F., Spinale, F.G., and Mann, D.G. (2001) Left ventricular remodeling in transgenic mice with cardiac-restricted overexpression of tumor necrosis factor. Circulation, 104(7):826-831.

Horwich, T., Fonarow, G.C., Hamilton, MA, MacLellan, W.R., Woo, M., Tillisch, J. (2001) The relationship between obesity and mortality in patients with heart failure. J. Am. Coll Card. 38(3):789-795.

Xiao, G., Mao, S., Baumgarten, G., Serrano, J., Jordan, M., Roos, K., Fishbein, M., and MacLellan, W. R. (2001) Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis. (in press).