Curriculum Vitae

Research Interest

Molecular biology of sodium and calcium transport; cardiac excitation-contraction coupling

Representative Publications

Qiu, Z., Nicoll, D.A. and Philipson, K.D. Helix packing of functionally important regions of the cardiac Na+-Ca2+ exchanger. J. Biol. Chem. 276:194-199, 2001.

Terracciano, C.M.N., Philipson, K.D. and MacLeod, K.T. Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice. Cardiovasc. Res. 49:38-47, 2001.

Weber, C.R., Ginsburg, K.S., Philipson, K.D., Shannon, T.R. and Bers, D.M. Allosteric regulation of Na/Ca exchanger current by cytosolic Ca in intact cardiac myocytes. J. Gen. Physiol. 117:119-131, 2001.

Ottolia, M. John, S., Qiu, Z. and Philipson, K.D. "Split" Na+-Ca2+ exchangers: implications for function and expression. J. Biol. Chem. 276:19603-19609, 2001.

Philipson, K.D., Gallivan, J.P., Brandt, G.S., Dougherty, D.A. and Lester, H.A. Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic acetylcholine receptor. Am. J. Physiol. 281:C195-C206, 2001.

Kraev, A., Quednau, B.D., Leach, S., Li, X.-F., Dong, H., Winkfein, R., Perizzolo, M., Cai, X., Yang, R., Philipson, K.D. and Lytton, J. Molecular cloning of a third membere of the potassium-dependent sodium-calcium exchange gene family, NCKX3. J. Biol. Chem. 276:23161-23172, 2001.

Qiu, Z., Chen, J., Nicoll, D.A. and Philipson, K.D. A disulfide bond is required for functional assembly of NCX1 from complementary fragments. Biochem. Biophys. Res. Commun. 287:825-828, 2001.

Sugishita, K., Su, Z., Li, F., Philipson, K.D. and Barry, W.H. Gender influences [Ca2+]i during metabolic inhibition in myocytes overexpressing the Na+-Ca2+ exchanger. Circulation 104:2101-2106, 2001.

Reuter, H., Henderson, S.A., Han, T., Ross, R.S., Goldhaber, J.I. and Philipson, K.D. The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ. Res. 90:305-308, 2002.

Reuter, H., Henderson, S.A., Han, T., Matsuda, T., Baba, A., Ross, R.S., Goldhaber, J.I. and Philipson, K.D. Knock out mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors. Circ. Res. 91:90-92, 2002.

Min, J.Y., Sullivan, M.F., Yan, X., Feng, X., Chu, V., Wang, J.F., Amende, I., Morgan, J.P., Philipson, K.D. and Hampton, T.G. Overexpression of Na+-Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction. Am. J. Physiol. 283:H2466-H2471, 2002.