Curriculum Vitae
Research Interest
My research interest is to study of
the mechanisms and control of atrial and ventricular fibrillation in
animal models using single cell microelectrode recordings and
optical mapping techniques of cardiac activation.
Representative Publications
Ohara T, Qu, Z. Lee M-H,
Ohara K, Ohara K, Omichi C, Mandel WJ, Chen P-S,
< Karagueuzian HS. Increased vulnerability to inducible atrial fibrillation caused by partial cellular
uncoupling with heptanol. Am J Physiol , 283:H1116-1122,
2002
Yashima M, Miyauchi Y, Cao J-M, Kim Y-H,
Mandel WJ, Chen P-S, Karagueuzian HS: The mechanism of the
probabilistic nature of ventricular defibrillation threshold. Am J
Physiol, 284: H249-255, 2003
Swissa M, Ohara T, Lee M-H, Kaul S, M.D.
Shah PK, Chen P-S, Karagueuzian HS: Sildenafil-nitric oxide donor
combination promotes ventricular tachyarrhythmias in the swine right
ventricle. Am J Physiol, Heart & Circulatory Physiology, 282:
H1787-1792, 2002
Miyauchi Y, Ohara K, Ohara T, Fishbein
MC, Zhou S, Lee MH, Mandel WJ, Chen P-S, Karagueuzian HS: Altered
atrial electrical restitution and sympathetic hyperinnervation in
hearts with chronic left ventricular myocardial infarction.
Implications to atrial fibrillation. Circulation, 108:360-366, 2003
Miyauchi Y, Fishbein MC,
Karagueuzian
HS: Electrical current-induced atrial and pulmonary vein action
potential duration shortening and repetitive activity. Am J Physiol,
Heart & Circulatory Physiology, 287:H178-186, 2004
Miyauchi, M, Qu Z, Miyauchi Y, Zhou S-M,
Pak H, Mandel WJ, Fishbein MC, Chen P-S, Karagueuzian HS: Chronic
nicotine in hearts with healed ventricular myocardial infarction
promotes atrial flutter that resembles typical human atrial flutter.
Am J Physiol, Heart & Circulatory Physiology, 288:H2878-H2886, 2005
Miyauchi Y, Hayashi H, Miyauchi M,
Okuyama Y, Mandel WJ, Chen P-S, Karagueuzian HS: Heterogeneous
pulmonary vein myocardial cell repolarization: implications for
reentry and triggered activity. Heart Rhythm, 2:1339-1345, 2005
(Figure 1 of this paper made the cover of the Journal and an
editorial accompanied the article)
Ono N, Hayashi H, Kawase A, Lin S-F, Li
H, Weiss JN, Chen P-S, Karagueuzian HS: Spontaneous atrial
fibrillation initiated by triggered activity near the pulmonary
veins in aged rats subjected to glycolytic inhibition. Am J Physiol
(Heart & Circulatory Physiology), 292:H639-H648, 2007. (Figure 9 of
this paper made the cover of the Journal)
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